Estrogen receptor antagonism exacerbates cardiac structural and functional remodeling in female rats

MC El Hajj, VK Ninh, EC El Hajj… - American Journal …, 2017 - journals.physiology.org
We have previously demonstrated the cardioprotective effects of ovarian hormones against
adverse ventricular remodeling imposed by chronic volume overload. Here, we assess the …

Estrogen attenuates chronic volume overload induced structural and functional remodeling in male rat hearts

JD Gardner, DB Murray… - American Journal …, 2010 - journals.physiology.org
We have previously reported gender differences in ventricular remodeling and development
of heart failure using the aortocaval fistula model of chronic volume overload in rats. In …

Gender mediated cardiac protection from adverse ventricular remodeling is abolished by ovariectomy

GL Brower, JD Gardner, JS Janicki - Molecular and cellular biochemistry, 2003 - Springer
Gender differences in the prevalence of cardiovascular disease have been observed both
clinically and experimentally. These cardioprotective effects have frequently been attributed …

Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogens

JD Gardner, GL Brower… - American Journal of …, 2008 - journals.physiology.org
Intact female rats fed a high-phytoestrogen diet are protected against adverse left ventricular
(LV) remodeling induced by chronic volume overload. We hypothesized that both …

Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats

MS Bhuiyan, N Shioda… - American Journal of …, 2007 - journals.physiology.org
To elucidate the molecular mechanism underlying estrogen-mediated cardioprotection in left
ventricular (LV) hypertrophy and remodeling, we analyzed myocardial hypertrophy as well …

Treatment with an estrogen receptor-beta-selective agonist is cardioprotective

I Nikolic, D Liu, JA Bell, J Collins, C Steenbergen… - Journal of molecular and …, 2007 - Elsevier
This study was designed to investigate whether treatment with an estrogen receptor-beta
(ER-β)-selective agonist (2, 3-bis (4-hydroxyphenyl)-propionitrile, DPN) can provide …

Female sex and estrogen receptor-β attenuate cardiac remodeling and apoptosis in pressure overload

D Fliegner, C Schubert, A Penkalla… - American Journal …, 2010 - journals.physiology.org
We investigated sex differences and the role of estrogen receptor-β (ERβ) on myocardial
hypertrophy in a mouse model of pressure overload. We performed transverse aortic …

Effects of dietary phytoestrogens on cardiac remodeling secondary to chronic volume overload in female rats

JD Gardner, GL Brower… - Journal of Applied …, 2005 - journals.physiology.org
Previously, we demonstrated that intact female rats fed a standard rodent diet containing
soybean products exhibit essentially no adverse left ventricular (LV) remodeling in response …

Oestrogen modulates cardiac ischaemic remodelling through oestrogen receptor‐specific mechanisms

FA Babiker, DJ Lips, E Delvaux, P Zandberg… - Acta …, 2007 - Wiley Online Library
Aim: Observational and clinical studies suggest different responses upon sex hormone
replacement therapy in ischaemic heart disease. Few studies, however, have examined the …

Rescue of pressure overload‐induced heart failure by estrogen therapy

A Iorga, J Li, S Sharma, S Umar… - Journal of the …, 2016 - Am Heart Assoc
Background Estrogen pretreatment has been shown to attenuate the development of heart
hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF) …