Estrogen receptor antagonism exacerbates cardiac structural and functional remodeling in female rats
MC El Hajj, VK Ninh, EC El Hajj… - American Journal …, 2017 - journals.physiology.org
We have previously demonstrated the cardioprotective effects of ovarian hormones against
adverse ventricular remodeling imposed by chronic volume overload. Here, we assess the …
adverse ventricular remodeling imposed by chronic volume overload. Here, we assess the …
Estrogen attenuates chronic volume overload induced structural and functional remodeling in male rat hearts
JD Gardner, DB Murray… - American Journal …, 2010 - journals.physiology.org
We have previously reported gender differences in ventricular remodeling and development
of heart failure using the aortocaval fistula model of chronic volume overload in rats. In …
of heart failure using the aortocaval fistula model of chronic volume overload in rats. In …
Gender mediated cardiac protection from adverse ventricular remodeling is abolished by ovariectomy
GL Brower, JD Gardner, JS Janicki - Molecular and cellular biochemistry, 2003 - Springer
Gender differences in the prevalence of cardiovascular disease have been observed both
clinically and experimentally. These cardioprotective effects have frequently been attributed …
clinically and experimentally. These cardioprotective effects have frequently been attributed …
Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogens
JD Gardner, GL Brower… - American Journal of …, 2008 - journals.physiology.org
Intact female rats fed a high-phytoestrogen diet are protected against adverse left ventricular
(LV) remodeling induced by chronic volume overload. We hypothesized that both …
(LV) remodeling induced by chronic volume overload. We hypothesized that both …
Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats
MS Bhuiyan, N Shioda… - American Journal of …, 2007 - journals.physiology.org
To elucidate the molecular mechanism underlying estrogen-mediated cardioprotection in left
ventricular (LV) hypertrophy and remodeling, we analyzed myocardial hypertrophy as well …
ventricular (LV) hypertrophy and remodeling, we analyzed myocardial hypertrophy as well …
Treatment with an estrogen receptor-beta-selective agonist is cardioprotective
I Nikolic, D Liu, JA Bell, J Collins, C Steenbergen… - Journal of molecular and …, 2007 - Elsevier
This study was designed to investigate whether treatment with an estrogen receptor-beta
(ER-β)-selective agonist (2, 3-bis (4-hydroxyphenyl)-propionitrile, DPN) can provide …
(ER-β)-selective agonist (2, 3-bis (4-hydroxyphenyl)-propionitrile, DPN) can provide …
Female sex and estrogen receptor-β attenuate cardiac remodeling and apoptosis in pressure overload
D Fliegner, C Schubert, A Penkalla… - American Journal …, 2010 - journals.physiology.org
We investigated sex differences and the role of estrogen receptor-β (ERβ) on myocardial
hypertrophy in a mouse model of pressure overload. We performed transverse aortic …
hypertrophy in a mouse model of pressure overload. We performed transverse aortic …
Effects of dietary phytoestrogens on cardiac remodeling secondary to chronic volume overload in female rats
JD Gardner, GL Brower… - Journal of Applied …, 2005 - journals.physiology.org
Previously, we demonstrated that intact female rats fed a standard rodent diet containing
soybean products exhibit essentially no adverse left ventricular (LV) remodeling in response …
soybean products exhibit essentially no adverse left ventricular (LV) remodeling in response …
Oestrogen modulates cardiac ischaemic remodelling through oestrogen receptor‐specific mechanisms
FA Babiker, DJ Lips, E Delvaux, P Zandberg… - Acta …, 2007 - Wiley Online Library
Aim: Observational and clinical studies suggest different responses upon sex hormone
replacement therapy in ischaemic heart disease. Few studies, however, have examined the …
replacement therapy in ischaemic heart disease. Few studies, however, have examined the …
Rescue of pressure overload‐induced heart failure by estrogen therapy
Background Estrogen pretreatment has been shown to attenuate the development of heart
hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF) …
hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF) …