Changes in apoptosis-related gene expression profiles in cancer cell lines exposed to usnic acid lichen secondary metabolite

AB Dincsoy, DC Duman - Turkish Journal of Biology, 2017 - journals.tubitak.gov.tr
The presence of uninhibited side effects of cancer drugs often used in cancer treatment has
stimulated the search for alternative therapeutic approaches. Therefore, anticarcinogenic …

Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and γ-H2A. X …

K Kumar, JPN Mishra, RP Singh - Chemico-biological interactions, 2020 - Elsevier
Usnic acid, a dibenzofuran derivative found in many lichen species, is reported to have
anticancer activity against human gastric cancer. We investigated the molecular alterations …

Usnic acid: a non-genotoxic compound with anti-cancer properties

M Mayer, MA O'Neill, KE Murray… - Anti-cancer …, 2005 - journals.lww.com
The majority of human tumors bear inactive p53 or cellular factors that down-regulate the
expression and activity of the p53 network. Therefore, finding therapies that are effective in …

Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells

N Singh, D Nambiar, RK Kale, RP Singh - Nutrition and cancer, 2013 - Taylor & Francis
Usnic acid (UA) is a secondary metabolite abundantly found in lichens. Some studies have
shown the anticancer potential of UA; however, its efficacy and associated mechanisms are …

Synthesis of usnic acid derivatives and evaluation of their antiproliferative activity against cancer cells

A Pyrczak-Felczykowska, R Narlawar… - Journal of natural …, 2019 - ACS Publications
Usnic acid is a secondary metabolite abundantly found in lichens, for which promising
cytotoxic and antitumor potential has been shown. However, knowledge concerning …

The role of usnic acid-induced apoptosis and autophagy in hepatocellular carcinoma

B Yurdacan, U Egeli, GG Eskiler… - Human & …, 2019 - journals.sagepub.com
Usnic acid (UA) is a multifunctional bioactive lichen secondary metabolite with potential anti-
cancer properties. Although the promising therapeutic effects of UA have been investigated …

Cellular mechanisms of the anticancer effects of the lichen compound usnic acid

E Einarsdóttir, J Groeneweg, GG Björnsdóttir… - Planta …, 2010 - thieme-connect.com
The lichen compound usnic acid is used for its antimicrobial activities in cosmetic products
and is also a component of slimming agents. Its effect against cancer cells was first noted …

Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis

S Ozturk, M Erkisa, S Oran, E Ulukaya… - Drug and chemical …, 2021 - Taylor & Francis
Successful cancer treatment still requires new complexes or compounds from natural
sources. Therefore, we investigated anti-growth/apoptotic effects of methanol extracts of the …

[HTML][HTML] Usnic acid induces cycle arrest, apoptosis, and autophagy in gastric cancer cells in vitro and in vivo

X Geng, X Zhang, B Zhou, C Zhang, J Tu… - … medical journal of …, 2018 - ncbi.nlm.nih.gov
Background Usnic acid (UA), a secondary metabolite, is mainly derived from certain lichen
species. Growing evidence suggests that UA has antitumor, anti-oxidative, anti …

Genotoxic, cytotoxic, and apoptotic effects of crude extract of Usnea filipendula Stirt. in vitro

SÇ KASIMOĞULLARI, S Oran, F Ari… - Turkish Journal of …, 2014 - journals.tubitak.gov.tr
Lichens are recently receiving great attention because they have potential anticancer
activity. Therefore, in this study, genotoxic and antigrowth properties of lichen species Usnea …