OBJECTIVE: The objective of our study was to evaluate whether ovarian suppression by two
different hormonal methods may spare the ovary the cytotoxic effects of isotretinoin in a rat …

Isotretinoin is a retinoid widely used for the treatment of severe nodulocystic acne. Although
it has broad side effects, there is no well-designed study about its effects on the ovary. This …

Abstract Isotretinoin (13-cis-retinoic acid), a derivative of vitamin A, is used in the treatment
of severe acne resulting in sebum suppression induced by sebocyte apoptosis. Isotretinoin …

Background: The study aims to determine the detrimental effects of 7.5 mg/kg/day
isotretinoin treatment on the anti-Mullerian hormone (AMH) levels in an experimental study …

Background/objective: Acne vulgaris is one of the most common diseases of the youth.
Systemic isotretinoin is the only drug which acts on all of the etiopathogenic mechanisms of …

Objective: Isotretinoin is used in acne vulgaris treatment for more than 20 years. Isotretinoin
has serious side effects on many organs, but there are no comprehensive studies …

Background/objective: Acne vulgaris is one of the most common diseases of the youth.
Systemic isotretinoin is the only drug which acts on all of the etiopathogenic mechanisms of …

Background: Isotretinoin (ISO) belongs to a family of drugs called retinoids. It is the most
effective drug prescribed by dermatologists for the treatment of the inflammatory disease …

Materials and Methods: Ninety-two reproductive women were included in this prospective
controlled study. Study group is consisted of 32 healthy control, 29 low-dose (0.4-0.6 …

Background: Isotretinoin affects the levels of female hormones and ovaries in patients with
severe acne. Objective: This study evaluated the effects of isotretinoin on the ovarian …