Prostate cancer is the most frequently diagnosed tumor in men and the second most
common cause of cancer-related death for males in the United States. It has been shown …

SKP2, an F-box protein of the SCF type of the E3 ubiquitin ligase complex, plays an
important function in driving tumorigenesis through the destruction of numerous tumor …

The F-box protein Skp2 (Fbl1) is a positive regulator of G1-S transition and promotes
ubiquitin-mediated proteolysis of the cyclin-dependent kinase inhibitor p27. Its …

The bioactive sphingolipid sphingosine-1-phosphate (S1P) drives several hallmark
processes of cancer, making the enzymes that synthesize S1P, that is, sphingosine kinase 1 …

Prostate cancer is the most commonly diagnosed tumor in men in the United States. Patients
with hormone-refractory prostate cancer are often treated with paclitaxel, but most of them …

Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for
various cellular processes whose dysregulation is linked to serious diseases including …

BACKGROUND The intervention of advanced prostate cancer (PCa) in patients has been
commonly depending on androgen deprivation therapy. Despite of tremendous research …

Skp2 is a crucial component of SCFSkp2 E3 ubiquitin ligase and is often overexpressed in
various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal …

The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the
key players regulating cell cycle progression is the F‐box protein Skp2. Skp2 forms a SCF …

BACKGROUND: In several human cancers, overexpression of Skp2 (S-phase kinase
associated protein 2), which targets p27 for degradation, portends a poorer prognosis. We …