The aim of this study was to investigate optimal loading doses prior to continuous infusion of
meropenem in critically ill patients. A previously published and successfully evaluated …

Objectives To compare the plasma and subcutaneous tissue concentration–time profiles of
meropenem administered by intermittent bolus dosing or continuous infusion to critically ill …

Abstract Background and Objectives Meropenem is frequently used for the treatment of
severe bacterial infections in critically ill patients. Because critically ill patients are more …

Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …

Purpose Patients admitted to intensive care unit (ICU) with Klebsiella pneumoniae infections
are characterized by high mortality. The aims of the present study were to investigate the …

Purpose In critically ill patients treated with meropenem, the proposed pharmacokinetics/
pharmacodynamics (PK/PD) efficacy index is to keep the free drug concentration 4–5 times …

The optimal method for administering meropenem remains controversial. This study was
conducted to explore the optimal two-step infusion strategy (TIT), and to investigate whether …

Purpose To develop a meropenem population pharmacokinetic model in critically ill patients
with particular focus on optimizing dosing regimens based on renal function. Methods …

Background: The proper dosage of antibiotics is a key element in the effective treatment of
infection, especially in critically ill patients. This study aimed to evaluate the efficacy of …

Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …