Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the
host to microbial infection and is the leading cause of death in intensive care units. The …

Significance: Sepsis is defined as a life-threatening organ dysfunction caused by
dysregulated host response to infection. This leads to an uncontrolled inflammatory …

Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …

In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular …

The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

Thermal injury is often associated with a proinflammatory state resulting in serious
complications. After a burn, the innate immune system is activated with subsequent immune …

Associated with the development of hospital-acquired infections, major traumatic injury
results in an immediate and persistent state of systemic immunosuppression, yet the …

“The danger/injury model” of Immunity, formulated twenty seven years ago, holds that the
immune system does not care about self vs. nonself, but rather that cell stress/tissue injury …