YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant growth in prostate cancer
The transcriptional co-activator Yes-associated protein 1 (YAP1), a key nuclear effector of
the Hippo pathway, is a potent oncogene, and yet, the interaction between YAP1 and …
the Hippo pathway, is a potent oncogene, and yet, the interaction between YAP1 and …
YAP antagonizes TEAD‐mediated AR signaling and prostate cancer growth
Hippo signaling restricts tumor growth by inhibiting the oncogenic potential of YAP/TAZ‐
TEAD transcriptional complex. Here, we uncover a context‐dependent tumor suppressor …
TEAD transcriptional complex. Here, we uncover a context‐dependent tumor suppressor …
The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells
Yes-associated protein (YAP) is an effector of the Hippo tumor suppressor pathway. The
functional significance of YAP in prostate cancer has remained elusive. In this study, we first …
functional significance of YAP in prostate cancer has remained elusive. In this study, we first …
The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer
Background After long-term androgen deprivation therapy, 25–30% prostate cancer (PCa)
acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key …
acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key …
The hippo pathway in prostate cancer
O Salem, CG Hansen - Cells, 2019 - mdpi.com
Despite recent efforts, prostate cancer (PCa) remains one of the most common cancers in
men. Currently, there is no effective treatment for castration-resistant prostate cancer …
men. Currently, there is no effective treatment for castration-resistant prostate cancer …
[HTML][HTML] Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension
Objective: Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a
transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p) YAP1 in …
transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p) YAP1 in …
ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer
CY Liu, T Yu, Y Huang, L Cui, W Hong - Journal of Biological Chemistry, 2017 - ASBMB
Prostate cancer is a very common malignant disease and a leading cause of death for men
in the Western world. Tumorigenesis and progression of prostate cancer involves multiple …
in the Western world. Tumorigenesis and progression of prostate cancer involves multiple …
NEK1 phosphorylation of YAP promotes its stabilization and transcriptional output
Simple Summary We earlier described the involvement of the TLK1> NEK1> ATR> Chk1
axis as a key determinant of cell cycle arrest in androgen-dependent prostate cancer (PCa) …
axis as a key determinant of cell cycle arrest in androgen-dependent prostate cancer (PCa) …
P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis
Abstract Yes-associated protein 1 (YAP1), a key player in the Hippo pathway, has been
shown to play a critical role in tumor progression. However, the role of YAP1 in prostate …
shown to play a critical role in tumor progression. However, the role of YAP1 in prostate …
RAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer
SE Lee, JU Lee, MH Lee, MJ Ryu, SJ Kim, YK Kim… - Oncogenesis, 2013 - nature.com
The transcription coactivator Yes-associated protein 1 (YAP1) is regulated by the Hippo
tumor suppressor pathway. However, the role of YAP1 in thyroid cancer, which is frequently …
tumor suppressor pathway. However, the role of YAP1 in thyroid cancer, which is frequently …