Rhodanines and related five-membered heterocycles with multiple heteroatoms have
recently gained a reputation of being unselective compounds that appear as “frequent …

Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …

Introduction: Rhodanine-based compounds have been associated with numerous biological
activities. After many years of research in drug discovery, they have gained a reputation as …

Rhodanines, thiazolidine-2, 4-diones and pseudothiohydantoins have become a very
interesting class of heterocyclic compounds since the introduction of various glitazones and …

Heterocycles are common fragments of the vast majority of marketed drugs. This is a
reflection of the central role that heterocycles play in modern drug design. They can serve as …

Four-membered rings are witnessing significant prominence in medicinal chemistry
discovery programs. For example, a search of the chemical databases shows exponential …

Rhodanine has been recognized as a privileged scaffold in medicinal chemistry due to its
well-known ability to demonstrate a broad range of biological activities. The possibility of …

The pyridazine ring is endowed with unique physicochemical properties, characterized by
weak basicity, a high dipole moment that subtends π-π stacking interactions and robust …

New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …

Heteroatoms constitute a very common fragment of a number of active pharmaceutical
ingredients as well as excipients; from the point of view of significance, it is all the same if …