Objective: To investigate the association between the analgesic effect of non-steroidal
antiinflammatory drugs (NSAIDs) and sodium channel 1.7 (Nav1. 7) expression in the …

Background Inflammation is a major cause of temporomandibular disorder‐related pain. The
N av1. 7 sodium channel has a critical function in pain perceptions. However, whether and …

Background. Women with temporomandibular disorders (TMDs) experience some
amelioration of pain during pregnancy. Progesterone increases dramatically and steadily …

Abstract Prostaglandin E 2 (PGE 2) is a key proinflammatory mediator that contributes to
inflammatory hyperalgesia. Voltage-gated sodium channel 1.7 (Na v 1.7) plays an important …

Background The proinflammatory cytokine interleukin-1β (IL-1β) drives pain by inducing the
expression of inflammatory mediators; however, its ability to regulate sodium channel 1.7 …

Background Temporomandibular disorders (TMDs) have the highest prevalence in women
of reproductive age. The role of estrogen in TMDs and especially in TMDs related pain is not …

We previously demonstrated that sodium channel 1.7 (Nav1. 7) in trigeminal ganglion (TG)
was a critical factor in temporomandibular joint (TMJ) inflammation-induced …

Background: Temporomandibular disorders (TMDs) are characterized by persistent orofacial
pain and have diverse etiologic factors that are not well understood. It is thought that central …

Objective: Temporomandibular disorders (TMD) are an assorted set of clinical conditions
characterized mainly by pain in the temporomandibular joint (TMJ). TMJ inflammation or …

Pulpitis causes significant changes in the peripheral nervous system, which induce
hyperalgesia. However, the relationship between neuronal activity and Nav1. 7 expression …