Objectives Genistein, a dietary constituent, modulates voltage-dependent and ligand-gated
ionic channels, suggesting that it could also attenuate inflammatory hyperalgesia. However …

We used a photochemical method to generate a partial ischemic injury to the infraorbital
branch of the trigeminal nerve in rats. Following injury, rats developed a bilateral persistent …

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of
inflammatory pain. It is well established that NSAIDs exert their analgesic effects by …

Tetrodotoxin-resistant (TTX-R) sodium channels NaV1. 8 and NaV1. 9 in sensory neurons
were known as key pain modulators. Comparing with the widely reported NaV1. 8, roles of …

In order to investigate a putative role for nitric oxide (NO) in the central nociceptive
processing following carrageenan-induced arthritis in the rat temporomandibular joint (TMJ) …

The aim of this study was to determine whether peripheral N-methyl-d-aspartate (NMDA)
receptors are involved in inflammation-induced mechanical hypersensitivity of the …

The aim of the present study was to examine the effects of preemptive analgesia on the
development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was …

Pulpitis often causes referred pain in opposing teeth. However, the precise mechanism
underlying ectopic pain associated with tooth-pulp inflammation remains unclear. We …

The present study investigated whether daily systemic administration of docosahexaenoic
acid (DHA) in rats could attenuate the hyperexcitability of trigeminal spinal nucleus caudalis …

Abstract The voltage sodium channel 1.8 (Na V 1.8) in the dorsal root ganglion (DRG)
neurons contributes to the initiation and development of chronic inflammatory and …