Dexmedetomidine, an α2‐adrenoceptor agonist, is widely used as a sedative and analgesic
agent in a number of clinical applications. However, little is known about the mechanism by …

Temporomandibular joint (TMJ) pain is characterized by persistent jaw pain associated with
dysfunction and tenderness of the temporomandibular muscles and joints. The aim of this …

During oral surgery and temporomandibular joint repositioning, pain hypersensitivity often
occurs due to irritation or inflammation of the nerve endings in the orofacial region …

Curcumin, a major bioactive component of turmeric, has diverse therapeutic effects such as
anti-inflammatory, antioxidant, anticancer, and antinociceptive activities. The acid-sensing …

Background Pain hypoalgesia has been reported in Rett syndrome patients, a severe
neurodevelopmental disorder which can be attributed to mutations in the methyl-CpG …

Tumor necrosis factor‐(TNF‐) α is a proinflammatory cytokine involved in the development
and maintenance of inflammatory and neuropathic pain. Its effects are mediated by two …

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve various
symptoms such as headache, arthralgia, and dental pain. While the primary mechanism of …

Pain symptoms in temporomandibular disorders (TMD) predominantly affect reproductive
women, suggesting that estrogen regulates pain perception. However, how estrogen …

Objective To investigate the participation of canonical Wnt and NF-κB signaling pathways in
an experimental model of chronic arthritis induced by methylated bovine serum albumin …

It is commonly accepted that psychological stress is closely associated with the occurrence
and development of chronic orofacial pain. However, the pathogenesis underlying this …