Excessive reactive oxygen species production by mitochondria (mtROS) is a key contributor
to age-related vascular endothelial dysfunction. We recently showed in a crossover design …

Excess reactive oxygen species production by mitochondria is a key mechanism of age-
related vascular dysfunction. Our laboratory has shown that supplementation with the …

Key points The development of age‐related arterial endothelial dysfunction, a key
antecedent of increased cardiovascular disease (CVD) risk, is mediated largely by reduced …

Background: Cardiovascular disease (CVD) is the leading cause of death worldwide and
aging is the primary risk factor for the development of CVD. The increased risk of CVD with …

Epidemiological studies demonstrated that even in the absence of other risk factors (eg,
diabetes, hypertension, hypercholesterolemia), vascular aging significantly increases …

Cardiovascular diseases (CVD) are the leading cause of death worldwide and aging is the
primary risk factor for CVD. The development of vascular dysfunction, including endothelial …

Significance: The vasculature responds to the respiratory needs of tissue by modulating
luminal diameter through smooth muscle constriction or relaxation. Coronary perfusion …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

Mitochondrial biogenesis is involved in the control of cell metabolism, signal transduction,
and regulation of mitochondrial reactive oxygen species (ROS) production. Despite the …

Nutritional supplements, calorie restriction, and life style change are the most effective
preventive strategies to improve mitochondrial function and reduce mitochondrial oxidative …