Immunization with heat‐killed Francisella tularensis LVS elicits protective antibody‐mediated immunity

CL Lavine, SR Clinton… - European journal of …, 2007 - Wiley Online Library
Francisella tularensis (FT) has been classified by the CDC as a category A pathogen
because of its high virulence and the high mortality rate associated with infection via the …

Francisella tularensis vaccines

PCF Oyston - Vaccine, 2009 - Elsevier
Francisella tularensis has attracted attention historically as a biological weapon, due to its
high infectivity in aerosols, and the severity of disease in humans. There is no licensed …

Oral immunization of mice with the live vaccine strain (LVS) of Francisella tularensis protects mice against respiratory challenge with virulent type A F. tularensis

R KuoLee, G Harris, JW Conlan, W Chen - Vaccine, 2007 - Elsevier
Francisella tularensis is a Gram-negative intracellular bacterium, and the causative agent of
tularemia. The infection can be initiated by various routes and can manifest itself in several …

Efficacy of the live attenuated Francisella tularensis vaccine (LVS) in a murine model of disease

M Green, G Choules, D Rogers, RW Titball - Vaccine, 2005 - Elsevier
A live attenuated vaccine Francisella tularensis live vaccine strain (LVS), that confers
protection against tularemia infection in a number of animal models including man was …

An improved Francisella tularensis live vaccine strain (LVS) is well tolerated and highly immunogenic when administered to rabbits in escalating doses using various …

MF Pasetti, L Cuberos, TL Horn, JD Shearer… - Vaccine, 2008 - Elsevier
Tularemia is a severe disease for which there is no licensed vaccine. An attenuated F.
tularensis live vaccine strain (LVS) was protective when administered to humans but safety …

Humoral and cell‐mediated immunity to the intracellular pathogen Francisella tularensis

GS Kirimanjeswara, S Olmos, CS Bakshi… - Immunological …, 2008 - Wiley Online Library
Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is
increasingly being isolated in the United States and several European countries. The …

Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly …

JW Conlan, H Shen, R KuoLee, X Zhao, W Chen - Vaccine, 2005 - Elsevier
Francisella tularensis is an extremely virulent facultative intracellular bacterial pathogen of
many mammalian species including mice and humans in which it causes a spectrum of …

Inactivated Francisella tularensis Live Vaccine Strain Protects against Respiratory Tularemia by Intranasal Vaccination in an Immunoglobulin A-Dependent Fashion

SD Baron, R Singh, DW Metzger - Infection and immunity, 2007 - Am Soc Microbiol
Francisella tularensis is a gram-negative intracellular bacterium that is considered to be a
potential category A biological weapon due to its extreme virulence. Although vaccination …

Native Outer Membrane Proteins Protect Mice against Pulmonary Challenge with Virulent Type A Francisella tularensis

JF Huntley, PG Conley, DA Rasko… - Infection and …, 2008 - Am Soc Microbiol
Francisella tularensis is a gram-negative intracellular bacterium and the causative agent of
the zoonotic disease tularemia. F. tularensis is a category A select agent and thus a potential …

Oral Live Vaccine Strain-Induced Protective Immunity against Pulmonary Francisella tularensis Challenge Is Mediated by CD4+ T Cells and Antibodies, Including …

HJ Ray, Y Cong, AK Murthy, DM Selby… - Clinical and Vaccine …, 2009 - Am Soc Microbiol
Francisella tularensis is an intracellular gram-negative bacterium and the etiological agent
of pulmonary tularemia. Given the high degrees of infectivity in the host and of dissemination …