A multitude of new treatment options for individuals living with type 1 diabetes mellitus
(T1DM) are currently in development or have recently been approved. Recognizing the …

Diabetes mellitus is characterized by chronic hyperglycemia with disturbances of
carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin …

The discovery of insulin over 100 years ago provided a muchneeded lifeline for patients with
diabetes. Since that time patients with type 1 diabetes (T1DM) have seen progress in the …

Insulin therapy has advanced remarkably over the past few decades. Ultra-rapid-acting and
ultra-long-acting insulin analogs are now commercially available. Many additional insulin …

Diabetes mellitus (DM) is a progressive disease characterized by insulin deficiency and
insulin resistance or both. The fasting and post-prandial blood glucose is elevated, exposing …

Publisher Summary This chapter focuses on advances in therapeutic approaches to type 2
diabetes. In the US, about 10% of the diabetic population suffers from Type 1 diabetes, an …

David R. Owens, CBE, MD, FRCP Julio Rosenstock, MD glucose levels in diabetes, limited
only by hypoglycemia. Following the epochmaking discovery by Banting and Best in 1922, 1 …

Publisher Summary Several new mechanisms for the therapy of diabetes show considerable
promise for the expansion of the clinical options for the treatment of hyperglycemia. As new …

The discovery of insulin is one of the greatest milestones in medical history. This discovery
revolutionized the use of peptides and proteins as therapeutic agents. For more than six …

The first therapeutic use of insulin by Frederick Banting and Charles Best in 1921
revolutionized the management of type 1 diabetes and considerably changed the lives of …