Emodin is a natural bioactive compound from traditional Chinese herbs that exerts anti-
inflammatory, antioxidant, anticancer, hepatoprotective, and neuroprotective effects …

Acetaminophen (APAP) overdose may lead to the formation of oxidative stress, hepatocyte
apoptosis and necrosis, and, eventually result in acute liver failure. Escin, a major extracted …

Gastrodin is a major active phenolic glycoside extract from Gastrodia elata, an important
herb used in traditional medicine. Previous research has reported that gastrodin possesses …

Herbal medicines containing emodin, widely used for the treatment of hepatitis in clinic,
have been reported with hepatotoxicity in individuals. A modest inflammatory stress …

Acetaminophen‐(APAP‐) induced hepatic injury is an important clinical challenge. Oxidative
stress, inflammation, apoptosis, and endoplasmic reticulum stress (ERS) contribute to the …

Acetaminophen (APAP) overdose leads to liver injury. NLRP3 inflammasome is a key player
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …

Acetaminophen (APAP) overdose‐induced acute liver injury (ALI) causes hepatocyte cell
death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome …

Amlexanox, a clinically approved small-molecule therapeutic presently used to treat allergic
rhinitis, ulcer, and asthma, is an inhibitor of the noncanonical IkB kinase-ε (IKKε) and TANK …

Amygdalin is a natural compound from Bitter Apricot Seed which is reported to have anti-
inflammatory activity. Acetaminophen (APAP) resulted in drug-induced liver injury is the …

Acetaminophen (APAP) overdose-induced hepatotoxicity is the most common cause of drug-
induced liver injury worldwide, which is significantly linked to oxidative stress and sterile …