A Mutant of Francisella tularensis Strain SCHU S4 Lacking the Ability To Express a 58-Kilodalton Protein Is Attenuated for Virulence and Is an Effective Live Vaccine

S Twine, M Byström, W Chen, M Forsman… - Infection and …, 2005 - Am Soc Microbiol
Francisella tularensis subsp. tularensis (type A) strain SCHU S4 is a prototypic strain of the
pathogen that is highly virulent for humans and other mammals. Its intradermal (id) 50 …

The presence of infectious extracellular Francisella tularensis subsp. novicida in murine plasma after pulmonary challenge

JJ Yu, EK Raulie, AK Murthy, MN Guentzel… - European Journal of …, 2008 - Springer
Francisella tularensis is a gram-negative, facultative intracellular bacterium and is the
causative agent of the zoonotic disease tularemia [1]. F. tularensis has been considered a …

Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (ΔiglB) induces protective immunity against homotypic and heterotypic …

Y Cong, JJ Yu, MN Guentzel, MT Berton, J Seshu… - Vaccine, 2009 - Elsevier
Francisella tularensis, an intracellular Gram-negative bacterium, is the causative agent of
tularemia and a potential bioweapon. Currently, there is no licensed vaccine against this …

[HTML][HTML] The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell Signaling

JE Bröms, A Sjöstedt, M Lavander - Frontiers in microbiology, 2010 - frontiersin.org
Francisella tularensis is a highly virulent gram-negative intracellular bacterium that causes
the zoonotic disease tularemia. Essential for its virulence is the ability to multiply within host …

Attenuation and protective efficacy of an O-antigen-deficient mutant of Francisella tularensis LVS

J Li, C Ryder, M Mandal, F Ahmed, P Azadi… - …, 2007 - microbiologyresearch.org
Francisella tularensis is a zoonotic, Gram-negative coccobacillus that causes tularemia in
humans and animals. F. tularensis subspecies tularensis (type A) and F. tularensis …

Francisella tularensis as a potential agent of bioterrorism?

M Maurin - Expert Review of Anti-Infective Therapy, 2015 - Taylor & Francis
Francisella tularensis is a category A bioterrorism agent. It is the etiological agent of
tularemia, a zoonotic disease found throughout the northern hemisphere. The intentional …

Extensive Allelic Variation among Francisella tularensis Strains in a Short-Sequence Tandem Repeat Region

A Johansson, I Göransson, P Larsson… - Journal of clinical …, 2001 - Am Soc Microbiol
Members of the genus Francisella and the species F. tularensis appear to be genetically
very similar despite pronounced differences in virulence and geographic localization, and …

Construction and Characterization of an Attenuated Purine Auxotroph in a Francisella tularensis Live Vaccine Strain

R Pechous, J Celli, R Penoske, SF Hayes… - Infection and …, 2006 - Am Soc Microbiol
Francisella tularensis is a facultative intracellular pathogen and is the etiological agent of
tularemia. It is capable of escaping from the phagosome, replicating to high numbers in the …

Molecular Epidemiology of Francisella tularensis in the United States

KJ Kugeler, PS Mead, AM Janusz… - Clinical Infectious …, 2009 - academic.oup.com
Abstract Background. In the United States, tularemia is caused by Francisella tularensis
subsps. tularensis (type A) and holarctica (type B). Molecular subtyping has further divided …

[HTML][HTML] The Divergent Intracellular Lifestyle of Francisella tularensis in Evolutionarily Distinct Host Cells

M Ozanic, V Marecic, Y Abu Kwaik, M Santic - PLoS pathogens, 2015 - journals.plos.org
Francisella tularensis is a gram-negative, facultative, intracellular bacterium that survives in
mammals, arthropods, and amoebae; however, macrophages are considered the key cells …