Changing patterns in long-acting bronchodilator trials in chronic obstructive pulmonary disease

JF Donohue, PW Jones - International Journal of Chronic …, 2011 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
worldwide. Developments in the understanding of COPD have led to standard guidelines for …

[HTML][HTML] Daily variation in lung function in COPD patients with combined albuterol and ipratropium: results from a 4-week, randomized, crossover study

D Singh, CQ Zhu, S Sharma, A Church… - Pulmonary pharmacology …, 2015 - Elsevier
Background The bronchodilator response to short-acting β 2-agonist and short-acting
muscarinic antagonist monotherapies varies on a day-to-day basis within individual patients …

Bronchodilators in COPD: impact of β-agonists and anticholinergics on severe exacerbations and mortality

SR Salpeter - … Journal of Chronic Obstructive Pulmonary Disease, 2007 - Taylor & Francis
This review summarizes the long-term clinical outcomes associated with β-agonist and
anticholinergic bronchodilator use in patients with chronic obstructive pulmonary disease …

[引用][C] Combining dual bronchodilation and β-blockade in patients with an overlap between COPD and cardiovascular diseases

M Cazzola, MG Matera - Chest, 2018 - journal.chestnet.org
The well-established overlap between COPD and cardiovascular diseases (CVDs) suggests
that there is a strong need for COPD and CVD to be considered in an integrated way, 1 …

[HTML][HTML] What have we learned from observational studies and clinical trials of mild to moderate COPD?

M Barrecheguren, C González, M Miravitlles - Respiratory research, 2018 - Springer
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
worldwide. It is well established that patients with mild to moderate disease represent the …

Bronchodilator reversibility in COPD

NA Hanania, BR Celli, JF Donohue, UJ Martin - Chest, 2011 - Elsevier
COPD is a preventable and treatable disease characterized by airflow limitation that is not
fully reversible. The diagnosis of COPD is based on spirometric evidence of airways …

Anticholinergics in combination bronchodilator therapy in COPD

SI Rennard - Anticholinergic Agents in the Upper and Lower …, 1999 - taylorfrancis.com
Bronchodilators form one of the mainstays of therapy in patients with chronic obstructive
pulmonary disease (COPD). Aggressive use of these agents can often improve lung function …

Use of β-blockers and β-agonists in COPD: a review of clinical outcomes

SR Salpeter, NS Buckley - Respiratory Medicine: COPD Update, 2007 - Elsevier
Beta-blockers (β-blockers) reduce morbidity and mortality in many disease states, but had
been considered contraindicated in chronic obstructive pulmonary disease (COPD), due to …

Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: an overview and network meta-analysis

KM Kew, T Li - Cochrane Database of Systematic Reviews, 2013 - pure.johnshopkins.edu
This is the protocol for a review and there is no abstract. The objectives are as follows: To
assess the efficacy and safety of treatment options for patients whose chronic obstructive …

[HTML][HTML] Assessing the clinical value of fast onset and sustained duration of action of long-acting bronchodilators for COPD

M Cazzola, KM Beeh, D Price, N Roche - Pulmonary pharmacology & …, 2015 - Elsevier
The long-acting inhaled bronchodilators available for use in chronic obstructive pulmonary
disease (COPD) vary in their pharmacological class (β 2-adrenergic agonist or …