Cancer-specific alterations in DNA methylation are hallmarks of human malignancies;
however, the nature of the breast cancer epigenome and its effects on metastatic behavior …

Epigenetic profiling of tumor DNAs may reveal important new theranostic targets to improve
prognosis and treatment of advanced cancer patients. In this study, we performed a genome …

To better understand the biology of hormone receptor–positive and–negative breast cancer
and to identify methylated gene markers of disease progression, we carried out a genome …

Background Cancer cells undergo massive alterations to their DNA methylation patterns that
result in aberrant gene expression and malignant phenotypes. However, the mechanisms …

Background Breast cancer is a highly heterogeneous disease resulting in diverse clinical
behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that …

DNA methylation is aberrant in cancer, but the dynamics, regulatory role and clinical
implications of such epigenetic changes are still poorly understood. Here, reduced …

Background Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive breast
carcinoma. DNA methylation alterations are thought to be an early event in progression of …

Background Aberrant DNA methylation is frequently observed in breast cancer. However,
the relationship between methylation patterns and the heterogeneity of breast cancer has …

Background A number of clinico-pathological criteria and molecular profiles have been used
to stratify patients into high-and low-risk groups. Currently, there are still no effective …

Abstract Introduction Aberrant methylation of CpG islands is a hallmark of cancer and occurs
at an early stage in breast tumorigenesis. However, its impact on tumor development is not …