Objective The link between a reduced capacity for skeletal muscle mitochondrial fatty acid
oxidation (FAO) and lipotoxicity in human insulin resistance has been the subject of intense …

Context: Skeletal muscle insulin resistance is proposed to result from impaired skeletal
muscle lipid oxidative capacity. However, there is no evidence indicating that muscle lipid …

A reduction in fatty acid oxidation has been associated with lipid accumulation and insulin
resistance in the skeletal muscle of obese individuals. We examined whether this decrease …

Skeletal muscle from sedentary obese patients is characterized by depressed electron
transport activity, reduced expression of genes required for oxidative metabolism, altered …

A reduction in fatty acid (FA) oxidation has been associated with lipid accumulation and
insulin resistance in skeletal muscle of obese individuals. Numerous reports suggest that the …

A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been
proposed as a major factor leading to the accumulation of intramuscular lipids and their …

Abstract Background/Objectives Ectopic accumulation of lipids in skeletal muscle and the
formation of deleterious lipid intermediates is thought to contribute to the development of …

Aims/hypothesis Intramyocellular lipids, including diacylglycerol (DAG) and ceramides, have
been linked to insulin resistance. This randomised repeated-measures study examined the …

Obesity is associated with a decrement in the ability of skeletal muscle to oxidize lipid. The
purpose of this investigation was to determine whether clinical interventions (weight loss …

Previous studies have suggested that insulin resistance develops secondary to diminished
fat oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin …