Melanoma, which most often results from genome instability and malignant growth of
melanocytes, is a worldwide epidemic. As reported by the World Health Organization …

Human skin, eye and hair color rely on the production of melanin, depending on its quantity,
quality, and distribution, Melanin plays a monumental role in protecting the skin against the …

Melanins are pigment molecules that determine the skin, eye, and hair color of the human
subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide …

Abnormally high production of melanin or melanogenesis in skin melanocytes results in
hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These …

Increased production and accumulation of melanin are characteristics of a large number of
skin diseases, including melasma, post-inflammatory hyperpigmentation and lentigo. A …

Highlights•Different melanogenesis signaling pathways.•Human tyrosinase inhibitors have
been discussed.•Drug repositioning has been applied to find new agents.Melanin, primarily …

New genes regulating melanocyte biology and melanogenesis have been identified.
Furthermore, the dissection of the cell signalling pathways involved in the control of …

In humans, normal levels of pigmentation differ among races, and reflect quantitative and
qualitative differences in amount, size, and type of melanins synthesized and stored by …

Melanogenesis is a melanin-forming process responsible for protecting the skin against
ultraviolet radiation damage. An excess production of melanin, however, may result in …

Although melanin production is a key self-defense mechanism against ultraviolet radiation
(UVR)-induced skin damage, uneven or excessive deposition of melanin causes …