Regulation of carboxylesterases and its impact on pharmacokinetics and pharmacodynamics: an up-to-date review
ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
Carboxylesterase 1 and precision pharmacotherapy: pharmacogenetics and nongenetic regulators
Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …
The impact of carboxylesterases in drug metabolism and pharmacokinetics
L Di - Current drug metabolism, 2019 - ingentaconnect.com
Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …
A comprehensive functional assessment of carboxylesterase 1 nonsynonymous polymorphisms
Carboxylesterase 1 (CES1) is the predominant human hepatic hydrolase responsible for the
metabolism of many clinically important medications. CES1 expression and activity vary …
metabolism of many clinically important medications. CES1 expression and activity vary …
Functional study of carboxylesterase 1 protein isoforms
Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in
hydrolytic biotransformation of numerous medications. Considerable interindividual …
hydrolytic biotransformation of numerous medications. Considerable interindividual …
[HTML][HTML] Human carboxylesterases: a comprehensive review
D Wang, L Zou, Q Jin, J Hou, G Ge, L Yang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …
Clinical implications of genetic variation in carboxylesterase drug metabolism
Introduction: Mammalian carboxylesterase enzymes are a highly conserved metabolic
pathway involved in the metabolism of endogenous and exogenous compounds including …
pathway involved in the metabolism of endogenous and exogenous compounds including …
The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect
Z Merali, S Ross, G Paré - Drug metabolism and drug interactions, 2014 - degruyter.com
Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine
esterases responsible for the hydrolysis of ester and amide bonds present in a number of …
esterases responsible for the hydrolysis of ester and amide bonds present in a number of …
Human carboxylesterases and fluorescent probes to image their activity in live cells
Human carboxylesterases (CESs) are serine hydrolases that are responsible for the phase I
metabolism of an assortment of ester, amide, thioester, carbonate, and carbamate …
metabolism of an assortment of ester, amide, thioester, carbonate, and carbamate …
Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry
Y Sato, A Miyashita, T Iwatsubo, T Usui - Drug Metabolism and Disposition, 2012 - ASPET
The aims of this study were to develop a robust method for simultaneous quantification of
carboxylesterases (CESs) 1 and 2 and to quantify those absolute protein levels in human …
carboxylesterases (CESs) 1 and 2 and to quantify those absolute protein levels in human …