Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading
to durable response rates. Important mechanisms of action of ICB therapy include …

Simple Summary Despite tremendous treatment efforts, cancer is still one of the leading
causes of death, with approximately 10 million deaths in 2020. In the last decade …

Cellular senescence is a permanent growth arrest that is broadly recognized to act as a
barrier against tumorigenesis. Senescence is predominant in premalignant tumors, and …

Although targeted therapy and immunotherapy greatly improve the outcome of melanoma,
drug resistance and low response rates still maintain the unsubstitutability of traditional …

Background Current immunotherapies still have limited successful rates among cancers. It is
now recognized that T cell functional state in the tumor microenvironment (TME) is a key …

Melanoma cells can enter the process of senescence, but whether they express a secretory
phenotype, as reported for other cells, is undetermined. This is of paramount importance …

Immune checkpoint blockade (ICB)-based or natural cancer immune responses largely
eliminate tumours. Yet, they require additional mechanisms to arrest those cancer cells that …

Normal cells possess a limited proliferative life span, after which they enter a state of
irreversible growth arrest, called replicative senescence, which acts as a potent barrier …

Here, we showed that the secretome of senescent melanoma cells drives basal melanoma
cells towards a mesenchymal phenotype, with characteristic of stems illustrated by …

Cellular senescence is an irreversible arrest of cell proliferation at the G1 stage of the cell
cycle in which cells become refractory to growth stimuli. Senescence is a critical and potent …