The tumor microenvironment (TME) is a major contributor to cancer malignancy including
development of therapeutic resistance, a process mediated in part through intercellular …

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …

In normal tissue, cell division is carefully regulated to maintain the correct proliferative
balance. Abnormal cell division underlies many hypoproliferative and hyperproliferative …

The senescence response is a potent tumor suppressor mechanism characterized by an
irreversible growth arrest in response to potentially oncogenic signals to prevent the …

Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective
response to oncogenic events, serving to eliminate early neoplastic cells from the …

Cellular senescence is an anti‐proliferative program that restricts the propagation of cells
subjected to different kinds of stress. Cellular senescence was initially described as a cell …

The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due
to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector …

Cancer incidence increases drastically with age. Of the many possible reasons for this, there
is the accumulation of senescent cells in tissues and the loss of function and proliferation …

Cellular senescence is a state of durable cell arrest that has been identified both in vitro and
in vivo. It is associated with profound changes in gene expression and a specific secretory …

Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …