Immunotherapies have revolutionized cancer treatment, but despite the many lives that have
been extended by these therapies many patients do not respond for reasons that are not …

Background and Aims The initiation of cellular senescence in response to protumorigenic
stimuli counteracts malignant progression in (pre) malignant cells. Besides arresting …

Cellular senescence is an important mechanism for preventing the proliferation of potential
cancer cells. Recently, however, it has become apparent that this process entails more than …

Senescent cells spread the word: non‐cell autonomous propagation of cellular senescence |
The EMBO Journal All EMBO Press journals Open Access as of 1 January 2024 - read the …

Background Interferon-γ (IFN-γ) plays an important role in the proceedings of vitiligo through
recruiting lymphocytes to the lesional skin. However, the potential effects of IFN-γ on skin …

Cellular senescence is a stress response associated with aging and disease, including
cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology …

Cellular senescence, the permanent state of cell-cycle arrest, is emerging as an intrinsic
barrier against tumorigenesis and a mechanism contributing to organismal ageing …

Highlights•Persistent DNA damage triggers a senescence-associated secretory
program.•p16 INK4a is a biomarker for senescence and aging but its levels do not predict …

Detection and quantification of senescent cells remain difficult due to variable phenotypes
and the absence of highly specific and reliable biomarkers. It is therefore widely accepted to …

Simple Summary Melanoma is a dreadful type of skin cancer with a poor response to
therapy. Senescent cells have been found to accumulate with age and may contribute to the …