Approximately 12% of the US population is Hispanic, with the majority residing in urban
centers such as Los Angeles. The prevalence of BRCA mutations among high-risk Hispanic …

Purpose To determine the prevalence and type of BRCA1 and BRCA2 (BRCA) mutations
among Hispanics in the Southwestern United States and their potential impact on genetic …

Purpose An accurate evaluation of the penetrance of BRCA1 and BRCA2 mutations is
essential to the identification and clinical management of families at high risk of breast and …

Background: Large rearrangements account for 8% to 15% of deleterious BRCA mutations,
although none have been characterized previously in individuals of Mexican ancestry …

The spectrum of mutations in BRCA1 and BRCA2 among African Americans has not been
well characterized because most studies to date have been done in Caucasian families …

Purpose BRCAPRO, a BRCA mutation carrier prediction model, was developed on the basis
of studies in individuals of Ashkenazi Jewish and European ancestry. We evaluated the …

Background: BRCA1 and BRCA2 mutations in general populations and in various types of
cancers have not been well characterized. We investigated the presence of these mutations …

ContextTen years after BRCA1 and BRCA2 were first identified as major breast cancer
susceptibility genes, the spectrum of mutations and modifiers of risk among many ethnic …

Data from several countries indicate that 1% to 2% of Ashkenazi Jews carry a pathogenic
ancestral mutation of the tumor suppressor gene BRCA1. However, the prevalence of …

Although well studied in families at high-risk, the roles of mutations in the BRCA1 and
BRCA2 genes are poorly understood in breast cancers in the general population …