Platinum derivatives used as chemotherapeutic drugs such as cisplatin and oxaliplatin have
a potent antitumor activity. However, severe side effects such as nephro-, oto-, and …

Organic cation transporter 2 (OCT2) mediates the initial step in renal secretion of organic
cations: uptake from the blood, across the basolateral membrane, and into the renal …

Introduction: Drug transporters play an important role in the absorption, distribution, and
excretion (ADE) of many drugs. In the last several years it has become increasingly clear …

Objectives The goals of this study were to determine the role of organic cation transporter 3
(OCT3) in the pharmacological action of metformin and to identify and functionally …

Endogenous substrates are emerging biomarkers for drug transporters, which serve as
surrogate probes in drug-drug interaction (DDI) studies. In this study, the results of …

Cimetidine decreases the renal clearance of metformin by inhibition of renal tubular cation
transport, and the underlying molecular mechanisms are still not fully understood. We …

The membrane transport of many cationic prescription drugs depends on facilitated transport
by organic cation transporters of which several members, including OCT2 (SLC22A2), are …

Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …

Picoplatin, a third-generation platinum agent, is efficacious against lung cancers that are
otherwise resistant or become refractory during platinum treatment. This effort was aimed at …

Polyspecific organic cation (OC) transporters play important roles in the disposition of
clinically used drugs, including drugs used during pregnancy. Pregnancy is known to alter …