A major goal in cancer and aging research is to discriminate the biochemical modifications
that happen locally that could account for the healthiness or malignancy of tissues …

Life expectancy has drastically increased over the last few decades worldwide, with
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …

Cellular senescence is an anti‐proliferative program that restricts the propagation of cells
subjected to different kinds of stress. Cellular senescence was initially described as a cell …

Can studying cultured cells inform us about the biology of aging? The idea that this may be
was stimulated by the first formal description of replicative senescence. Replicative …

Cellular senescence is a state of stable cell cycle arrest that is known to be elicited in
response to different stresses or forms of damage. Senescence limits the replication of old …

In response to cellular stress or damage, proliferating cells can induce a specific program
that initiates a state of long-term cell-cycle arrest, termed cellular senescence. Accumulation …

Cellular senescence constitutes a stress response mechanism in reaction to a plethora of
stimuli. Senescent cells exhibit cell‐cycle arrest and altered function. While cell‐cycle …

In recent years, cellular senescence has become the focus of attention in multiple areas of
biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by …

Normal cells do not divide indefinitely due to a process termed cellular or replicative
senescence. Several lines of evidence suggest that replicative senescence evolved to …

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …