Background Breast cancer negatively affects women's health worldwide. The tumour
microenvironment plays a critical role in tumour initiation, proliferation, and metastasis …

Breast cancer is a major health problem for women worldwide. Although in vitro culture of
established breast cancer cell lines is the most widely used model for preclinical …

To mimic the structure of breast tumor microenvironment, novel double-network poly (N ɛ-
acryloyl l-lysine)/hyaluronic acid (pLysAAm/HA) hydrogels were fabricated by a two-step …

Polysaccharide hydrogels are promising candidate matrices for recapitulating the
characteristics of extracellular matrix (ECM) in breast tumors in terms of their structure and …

In tumor biology, it is widely recognized that 3D rather than 2D cell culture can recapitulate
key features of solid tumors, including cell-extracellular matrix (ECM) interactions. In this …

The development of three-dimensional (3D) culture models is promising for cancer biology
studies and the discovery of new anticancer drugs because they mimic the in vivo situation …

Abstract The two‐dimensional (2D) models of breast cancer still exhibit a limited success.
Whereas, three‐dimensional (3D) models provide more similar conditions to the tumor for …

Purpose This study aimed to develop a hydrogel system for treating aggressive triple
negative breast cancer (TNBC) via kinetically-controlled delivery of the synergistic drug pair …

Abstract 2D cell culture is widely utilized to develop anti-cancer drugs and to explore the
mechanisms of cancer tumorigenesis and development. However, the findings obtained …

Cancer therapeutics are developed through extensive screening; however, many
therapeutics evaluated with 2D in vitro cultures during pre-clinical trials suffer from lower …