Reducing levels of 5-HT in the central nervous system has been associated with increases
in impulsive behavior. However, the impulsivity construct describes a wide range of …

Abstract Rationale Global serotonin (5-HT) depletion increases the number of premature
responses made on the five-choice serial reaction time task (5CSRT) in rats. In contrast, the …

Impulsiveness is a significant clinical problem associated with a variety of psychiatric and
neuropsychiatric disorders. Clinical and experimental studies have provided evidence that …

Rationale Specific brain structures have been suggested to be involved in impulsive
responding assessed by a variety of operant tasks. Central serotonin (5-HT) function has …

Converging lines of evidence suggest that dysfunction of brain serotonergic systems may
underlie impulsive behavior. However, the nature of this deficit remains poorly understood …

A series of ten experiments examined the effects of profound central 5-HT depletion on
attentional performance in the rat in the five-choice serial reaction time task, and also …

Impulsivity has often been assumed to be a unitary construct. However dissociable forms of
impulsive behaviour may exist, each with distinct neurochemical underpinnings. To test this …

Rationale Psychomotor stimulant drugs such as methylphenidate and amphetamine
decrease impulsive behaviour in attention deficit hyperactivity disorder patients by unknown …

Forebrain serotonergic lesions attenuate the ability of d-amphetamine to decrease
impulsivity in a delay-discounting paradigm, potentially through interactions between the …

This study investigated the acute effects of Δ 9-tetrahydrocannabinol (THC) on four
behavioral measures of impulsivity in recreational marijuana users. Although impulsive …