The prolactin (PRL) response to challenge with buspirone hydrochloride, a serotonin1a (5-
HT1a) receptor agonist, was examined in 5 healthy male volunteers and in 10 healthy male …

Updated theoretical accounts of the role of serotonin (5-HT) in motivation propose that 5-HT
operates at the intersection of aversion and inhibition, promoting withdrawal in the face of …

BACKGROUND: State-dependent changes in impulsivity may be related to norepinephrine.
To examine possible relationships between norepinephrine and acute changes in …

These studies addressed the question of serotonin (5-HT)-dopamine (DA) interactions with
regard to reward-related behavior and motor activity in rats. The first experiment evaluated …

Impulsive behavior is strongly implicated in drug abuse, as both a cause and a
consequence of drug use. To understand how impulsive behaviors lead to and result from …

The effects of various 5-HT 3 receptor antagonists were examined in the social interaction
(SI) test following discrete microinjection into either the dorsal raphe nucleus (DRN) or …

Abstract Central serotonin (5-HT) has been implicated in emotional and behavioral control
processes for many decades, but its precise contribution is not well understood. We used the …

The ability to make decisions and act quickly without hesitation can be advantageous in
many settings. However, when persistently expressed, impulsive decisions and actions are …

Deficits in attention and response inhibition are apparent across several neurodegenerative
and neuropsychiatric disorders for which current pharmacotherapy is inadequate. The 5 …

Rationale Many studies have shown that human drug abusers are more impulsive than
nonusers, but the mechanisms underlying this difference are unknown. C57BL/6J (B6) and …