Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity

NC Anastasio, SJ Stutz, LHL Fink… - ACS chemical …, 2015 - ACS Publications
A feature of multiple neuropsychiatric disorders is motor impulsivity. Recent studies have
implicated serotonin (5-HT) systems in medial prefrontal cortex (mPFC) in mediating …

Effects of selective dopaminergic compounds on a delay-discounting task

MN Koffarnus, AH Newman, P Grundt… - Behavioural …, 2011 - journals.lww.com
Impulsivity is widely regarded as a multidimensional trait that encompasses two or more
distinct patterns of behavior, and dopaminergic systems are implicated in the expression of …

Impulsivity and inhibitory control

GD Logan, RJ Schachar… - Psychological science, 1997 - journals.sagepub.com
We report an experiment testing the hypothesis that impulsive behavior reflects a deficit in
the ability to inhibit prepotent responses Specifically, we examined whether impulsive …

[引用][C] A behavioral dimension of constraint

RA Depue, MR Spoont - Annals of the New York Academy of …, 1986 - Wiley Online Library
Over the past decade there has been increasing evidence that reduced serotonergic (5HT)
activity, as indexed by cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) in living …

Limbic corticostriatal systems and delayed reinforcement

RN Cardinal, CA Winstanley… - Annals of the New …, 2004 - Wiley Online Library
Impulsive choice, one aspect of impulsivity, is characterized by an abnormally high
preference for small, immediate rewards over larger delayed rewards, and can be a feature …

Effect of lesions of the ascending 5-hydroxytryptaminergic pathways on choice between delayed reinforcers

MA Wogar, CM Bradshaw, E Szabadi - Psychopharmacology, 1993 - Springer
The possible involvement of the ascending 5-hydroxytryptaminergic (5HTergic) pathways in
determining the effectiveness of delayed positive reinforcers was investigated using Mazur's …

High trait impulsivity predicts food addiction-like behavior in the rat

C Velázquez-Sánchez, A Ferragud, CF Moore… - …, 2014 - nature.com
Impulsivity is a behavioral trait frequently seen not only in drug-addicted individuals but also
in individuals who pathologically overeat. However, whether impulsivity predates the …

Impulsivity, compulsivity, and top-down cognitive control

JW Dalley, BJ Everitt, TW Robbins - Neuron, 2011 - cell.com
Impulsivity is the tendency to act prematurely without foresight. Behavioral and
neurobiological analysis of this construct, with evidence from both animal and human …

DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum

TE Sipes, MA Geyer - Brain research, 1997 - Elsevier
Serotonin (5-HT) 2A receptors are known to be involved in prepulse inhibition of the startle
response (PPI), a measure of sensorimotor inhibition that is deficient in schizophrenia …

Changes in activities of dopamine and serotonin systems in the frontal cortex underlie poor choice accuracy and impulsivity of rats in an attention task

T Puumala, J Sirviö - Neuroscience, 1998 - Elsevier
The purpose of the present study was to investigate whether differences in the function of
monoaminergic systems could account for the variability in attention and impulsive …