Background This study aimed to investigate the effects of trimetazidine and l‑carnitine on
heart aging and cardiac metabolism in the natural aging rats and explore the possible …

Aging and diabetes mellitus (DM) both affect the structure and function of the myocardium,
resulting in increased collagen in the heart and reduced cardiac function. As part of this …

Purpose HFpEF (heart failure with preserved ejection fraction) is a major consequence of
diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita …

Advanced glycation end products (AGEs) and dendritic cells (DCs) are believed to play a
key role in the development and progression of cardiovascular diseases. However, their role …

Highlights•Cardiovascular disease (CVD) has many risk factors contributing to
development.•Advanced glycation endproducts (AGEs) contribute to many pathologies of …

Cigarette smoke exposure is associated with an increased risk of cardiovascular
complications. The role of advanced glycation end products (AGEs) is already well …

Growing evidence supports the role of advanced glycation end products (AGEs) in the
development of diabetic vascular complications and cardiovascular diseases (CVDs). We …

Objectives: The purpose of this study was to study aging-associated alterations in the
inflammatory and reparative response after myocardial infarction (MI) and their involvement …

Diabetic cardiomyopathy (DCM) causes heart failure and increases the mortality in diabetic
patients. Myocardial apoptosis and fibrosis are the main features of DCM and aging. The …

Information about heart failure with reduced ejection fraction (HFrEF) in women and the
potential effects of aging in the female heart is scarce. We investigated the vulnerability to …