Alterations of HDL's to piHDL's proteome in patients with chronic inflammatory diseases, and HDL-targeted therapies

V Vyletelová, M Nováková, Ľ Pašková - Pharmaceuticals, 2022 - mdpi.com
Chronic inflammatory diseases, such as rheumatoid arthritis, steatohepatitis, periodontitis,
chronic kidney disease, and others are associated with an increased risk of atherosclerotic …

The versatility of HDL: a crucial anti‐inflammatory regulator

MD Säemann, M Poglitsch, C Kopecky… - European journal of …, 2010 - Wiley Online Library
Eur J Clin Invest 2010; 40 (12): 1131–1143 Abstract Background Low levels of plasma high‐
density lipoprotein (HDL) represent a major cardiovascular risk factor and therefore raising …

HDL in the 21st century: a multifunctional roadmap for future HDL research

A Rohatgi, M Westerterp, A Von Eckardstein… - Circulation, 2021 - Am Heart Assoc
Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia
that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular …

The HDL proteome: a marker–and perhaps mediator–of coronary artery disease

JW Heinecke - Journal of lipid research, 2009 - ASBMB
One important cardioprotective function of HDL is to remove cholesterol from lipid-laden
macrophages in the artery wall. HDL also exerts anti-inflammatory effects that might inhibit …

Inflammation alters HDL composition and function: implications for HDL-raising therapies

G Marsche, MD Saemann, A Heinemann… - Pharmacology & …, 2013 - Elsevier
There is clear epidemiological evidence that plasma levels of high-density lipoprotein (HDL)-
cholesterol are inverse and independent predictors of cardiovascular disease risk, fuelling …

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

AS Bhale, O Meilhac, CL d'Hellencourt… - …, 2024 - Wiley Online Library
High‐density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular
health, as they are intricately involved in cholesterol transport and inflammation modulation …

Dysfunctional HDL: the journey from savior to slayer

C Serban, D Muntean, DP Mikhailids… - Clinical Lipidology …, 2014 - search.proquest.com
HDL has many functions such as reverse cholesterol transport, anti-inflammation and
antioxidation. Different clinical conditions associated with inflammation, oxidation, advanced …

[PDF][PDF] Dysfunctional HDL: from structure-function-relationships to biomarkers

M Riwanto, L Rohrer, A von Eckardstein… - High Density …, 2015 - library.oapen.org
Reduced plasma levels of HDL-C are associated with an increased risk of CAD and
myocardial infarction, as shown in various prospective population studies. However, recent …

HDL and inflammation in atherosclerosis

LE Spieker, F Ruschitzka, TF Luscher… - Current Drug Targets …, 2004 - ingentaconnect.com
Atherosclerotic vascular disease is among the most frequent causes of death worldwide.
Current therapeutic strategies concentrate mainly on lowering of low-density lipoprotein …

The role and function of HDL in patients with diabetes mellitus and the related cardiovascular risk

M Femlak, A Gluba-Brzózka… - Lipids in health and …, 2017 - Springer
Background Diabetes mellitus (DM) is a major public health problem which prevalence is
constantly raising, particularly in low-and middle-income countries. Both diabetes mellitus …