The Toxicology of Crystalline Silica Studied In Vitro

KE Driscoll - Applied Occupational and Environmental Hygiene, 1995 - Taylor & Francis
In vitro assays have been used extensively to investigate the toxicity of mineral dusts,
including the various forms of crystalline silica. Early in vitro research utilized hemolysis and …

Does the crystal habit modulate the genotoxic potential of silica particles? A cytogenetic evaluation in human and murine cell lines

P Guidi, M Nigro, M Bernardeschi, P Lucchesi… - … /Genetic Toxicology and …, 2015 - Elsevier
Crystalline silica inhaled from occupational sources has been classified by IARC as
carcinogenic to humans; in contrast, for amorphous silica, epidemiological and experimental …

Crystalline silica: risks and policy.

TS Hardy, H Weill - Environmental Health Perspectives, 1995 - ehp.niehs.nih.gov
Since the International Agency for Research on Cancer labeled crystalline silica a probable
carcinogen in 1988, government regulations have required sand and other products to …

[PDF][PDF] Crystalline silica: variability in fibrogenic potency

M Meldrum, P Howden - Annals of Occupational Hygiene, 2002 - Citeseer
There is a growing body of evidence supporting the contention that the ability of respirable
crystalline silica to cause silicosis can vary according to the surrounding circumstances of …

Epidemiological evidence on the carcinogenicity of silica: factors in scientific judgement

CA Soutar, A Robertson, BG Miller, A Searl… - The Annals of …, 2000 - Elsevier
In view of the extended debate and differing opinions on whether crystalline silica is a
human carcinogen, we have reviewed a selection of epidemiological reports, to identify the …

Cancer risk assessment for crystalline silica to implement California's Hot Spots Act

JF Collins, MA Marty - Scandinavian Journal of Work, Environment & Health, 1995 - JSTOR
Crystalline silica has been identified as a probable human carcinogen. To assess the
potential for adverse health effects due to environmental exposures to respirable crystalline …

Occupational exposure to crystalline silica at Alberta work sites

D Radnoff, MS Todor, J Beach - Journal of occupational and …, 2014 - Taylor & Francis
Although crystalline silica has been recognized as a health hazard for many years, it is still
encountered in many work environments. Numerous studies have revealed an association …

Noncancer inhalation toxicology of crystalline silica: exposure-response assessment.

JS Gift, RA Faust - Journal of Exposure Analysis and Environmental …, 1997 - europepmc.org
Silicosis from inhalation of silica has long been recognized as an occupational hazard.
Concern has arisen regarding the potential risk of silicosis from ambient silica (primarily …

Health hazards due to the inhalation of amorphous silica

R Merget, T Bauer, H Küpper, S Philippou, H Bauer… - Archives of …, 2002 - Springer
Occupational exposure to crystalline silica dust is associated with an increased risk for
pulmonary diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive …

The carcinogenic action of crystalline silica: a review of the evidence supporting secondary inflammation-driven genotoxicity as a principal mechanism

PJA Borm, L Tran, K Donaldson - Critical reviews in toxicology, 2011 - Taylor & Francis
In 1987 the International Agency for Research on Cancer (IARC) classified crystalline silica
(CS) as a probable carcinogen and in 1997 reclassified it as a Group 1 carcinogen, ie, that …