Uterine leiomyomas exhibit fewer stem/progenitor cell characteristics when compared with corresponding normal myometrium

HL Chang, TN Senaratne, LH Zhang, PP Szotek… - Reproductive …, 2010 - Springer
Uterine leiomyomas (also known as uterine fibroids) are the most common benign tumors of
female reproductive tract and are the single most common indication for hysterectomies …

Subtype-specific tumor-associated fibroblasts contribute to the pathogenesis of uterine leiomyoma

X Wu, VA Serna, J Thomas, W Qiang, ML Blumenfeld… - Cancer research, 2017 - AACR
Recent genomic studies have identified subtypes of uterine leiomyoma (LM) with distinctive
genetic alterations. Here, we report the elucidation of the biological characteristics of the two …

Treatment strategies for uterine leiomyoma: the role of hormonal modulation

JD Cook, CL Walker - Seminars in reproductive medicine, 2004 - thieme-connect.com
Uterine leiomyomas are the most common gynecological tumors and are a significant health
concern for many women. Although the exact etiology of these tumors is unknown …

Advances in uterine leiomyoma research: the progesterone hypothesis

MS Rein - Environmental health perspectives, 2000 - JSTOR
Uterine leiomyomas are monoclonal tumors. However, the factors involved in their initiation
and growth remain poorly understood. The neoplastic transformation of myometrium to …

Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances

G Levy, MJ Hill, S Beall, SM Zarek, JH Segars… - Journal of assisted …, 2012 - Springer
Purpose Uterine leiomyomas are common, benign, reproductive tract tumors affecting a
majority of reproductive aged women. They are associated with gynecologic morbidity and …

Progesterone is essential for maintenance and growth of uterine leiomyoma

H Ishikawa, K Ishi, VA Serna, R Kakazu… - …, 2010 - academic.oup.com
Uterine leiomyomata (ULs) represent the most common tumor in women and can cause
abnormal uterine bleeding, large pelvic masses, and recurrent pregnancy loss. Although the …

Uterine leiomyomas: mechanisms of tumorigenesis

KD Houston, DS Hunter, LC Hodges… - Toxicologic …, 2001 - journals.sagepub.com
Uterine leiomyomas, also called fi broids, are the most common reproductive tract neoplasm
and the leading indication for hysterectomy in premenopausal women. The discovery and …

Effects of progesterone on uterine leiomyoma growth and apoptosis

T Maruo, H Matsuo, T Samoto, Y Shimomura… - Steroids, 2000 - Elsevier
Uterine leiomyomas appear during the reproductive years and regress after menopause,
indicating the ovarian steroid-dependent growth potential. Recently we have found that the …

Identification of new therapies for leiomyomas: what in vitro studies can tell us

RA Nowak - Clinical Obstetrics and Gynecology, 2001 - journals.lww.com
Uterine leiomyomas, or fibroids, are the most common pelvic tumors in women, with a
reported incidence of 20–25%. 1–3 Leiomyomas are clinically important because they are a …

[HTML][HTML] Progesterone signaling in uterine leiomyoma biology: Implications for potential targeted therapy

W Szucio, P Bernaczyk, D Ponikwicka-Tyszko… - Advances in Medical …, 2024 - Elsevier
Uterine leiomyomas (ULs) are the most common benign smooth muscle cell steroid-
dependent tumors that occur in women of reproductive age. Progesterone (P4) is a major …