We used a PCR-based subtraction method, representational difference analysis of cDNA
(cDNA–RDA), to identify genes with a higher expression in leiomyomas in comparison with …

Although the traditional concept supports a crucial role of estrogen in promoting leiomyoma
growth, unequivocal evidence has emerged indicating that progesterone also plays a vital …

The uterus is essential for reproduction in most mammalian species and is arguably the
most naturally plastic organ in terms of tissue remodeling in mammals. Histologically, the …

Smooth muscle tumors are histologically separated into benign leiomyomas and malignant
leiomyosarcomas. Uterine leiomyomas represent benign clonal tumors often arising within …

Uterine leiomyomas, benign uterine smooth muscle tumors that affect 30% of reproductive-
aged women, are a significant health concern. The initiation event for these tumors is …

Uterine leiomyoma, commonly known as fibroids, is a benign neoplasm of smooth muscle in
women. The incidence of clinically symptomatic fibroids in reproductive-age women is …

Uterine leiomyomas develop during the reproductive years and regress after menopause,
indicating ovarian steroid‐dependent growth potential. Although the clinical and …

Uterine leiomyomata, or fibroids, are benign tumors of the uterine myometrium that
significantly affect up to 30% of reproductive-age women. Despite being the primary cause …

Uterine leiomyomas are extremely common neoplasms that by the age of 50 are found in the
uterus of almost 70% of white women and more than 80% of women of African ancestry. 1 …

OBJECTIVE: To summarize the information regarding pathogenetic factors of leiomyoma
formation and growth, and to make a simple integrated pathogenetic view of this tumor for …