We previously reported that the biliary excretion of flomoxef, an oxacephem antibiotic, was
greater after dosing at 21: 00 than at 09: 00h in diurnally active human subjects. The present …

Aims To examine diurnal variation in biliary excretion of flomoxef. Methods Flomoxef (1 g)
was injected intravenously in eight patients with percutaneous transhepatic …

Flomoxef (FMOX), a new broad spectrum oxacephem antibiotic, was studied in the neonatal
field and the pharmacokinetic results obtained are summarized below. 1. Serum …

1. Following multiple oral administration of 14C-flocoumafen to rats at 0· 02 and 0· 1 mg/kg
per week, appreciable cellular accumulation was seen in the liver. 2. Residues in the liver …

1. Appreciable penetration of radioacticity occurred through rat skin following percutaneous
administration of 14C-flocoumafen. At 7 days after dosing 12% of the administered …

Clinical pharmacology and efficacy of flomoxef (FMOX) in neonates were investigated. And
the following results were obtained. 1. Mean serum concentrations of FMOX at 30 minutes …

Flomoxef is a new oxacephem of broad antibacterial activity. The compound is mainly
excreted through the kidneys. Two dose finding studies in patients with various degrees of …

Patients with biliary tract infections received 800 mg of fleroxacin orally once daily on five
consecutive days; cholecystectomy was on day 3. Starting on the day when dose 5 was …

Serum concentrations, urinary excretion and clinical responses of flomoxef (FMOX) were
studied. The results are summarized as follows. 1. Serum concentrations of FMOX were 17.4 …

We have previously reported that a time-dependent variation is observed in the diuretic
effect of furosemide and the light-dark cycle is a potent zeitgeber for this …