The transcription factor NF-κB is a pivotal regulator of inflammatory responses. While the
activation of NF-κB in the arthritic joint has been associated with rheumatoid arthritis (RA), its …

Osteoarthritis (OA) is an autoimmune disease associated with increasing age. Typically,
chondrocyte senescence is believed to serve an important role in the development and …

Objective: It is well known that expression of markers for WNT signaling is dysregulated in
osteoarthritic (OA) bone. However, it is still not fully known if the expression of these markers …

Endochondral ossification is important for skeletal development. Recent findings indicate
that the p65 (RelA) subunit, a main subunit of the classical nuclear factor-κB (NF-κB) …

Osteoarthritis (OA) is the most prevalent joint disease, characterized by the degradation of
articular cartilage, synovial inflammation, and changes in periarticular and subchondral …

In comparison with hip fractures, increased expression of genes in the Wnt pathway and
increased Wnt activity were found in bone samples and osteoblast cultures from patients …

Osteoarthritis (OA) is a joint disease, and few treatments to date have been able to delay OA
progression. The degradation of collagen type II (COL2) in the cartilage matrix is an …

Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA)
pathology. We searched for a pre-approved drug that suppresses abnormally activated …

OSTEOARTHRITIS, A JOINT disorder characterized by car-tilage degradation and
osteophyte formation, is considered a major public health issue causing chronic disability …

OBJECTIVE: We have previously reported that interleukin-1β (IL-1β) up-regulates the
expression of Wnt-5A and the activation of Wnt-5A signaling induces matrix …