Wnt/β-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover

R Yasuhara, T Yuasa, JA Williams, SW Byers… - Journal of Biological …, 2010 - ASBMB
Activation of the Wnt/β-catenin and retinoid signaling pathways is known to tilt cartilage
matrix homeostasis toward catabolism. Here, we investigated possible interactions between …

WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-κB pathways

EW Bradley, MH Drissi - Molecular endocrinology, 2010 - academic.oup.com
Although genetic evidence demonstrated a requirement for Wnt5a during cartilage
development, little is known about the mechanisms underlying Wnt5a-regulated …

[HTML][HTML] NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis

JA Roman-Blas, SA Jimenez - Osteoarthritis and cartilage, 2006 - Elsevier
The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response …

Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes

M Sen, J Reifert, K Lauterbach, V Wolf… - … : Official Journal of …, 2002 - Wiley Online Library
Objective The enhanced release of extracellular matrix proteins by fibroblast‐like
synoviocytes (FLS) from rheumatoid arthritis (RA) patients is suggestive of joint remodeling …

Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway

T He, D Wu, L He, X Wang, B Yang, S Li… - The FASEB …, 2020 - Wiley Online Library
Osteoarthritis (OA) is a high‐morbidity skeletal disease worldwide and the exact
mechanisms underlying OA pathogenesis are not fully understood. Casein kinase 1 epsilon …

LRP8 mediates Wnt/β‐catenin signaling and controls osteoblast differentiation

J Zhang, X Zhang, L Zhang, F Zhou… - Journal of bone and …, 2012 - academic.oup.com
The Wnt/β‐catenin signaling pathway plays a pivotal role in regulating osteoblast
differentiation and bone formation. Here, we identify low‐density lipoprotein (LDL) receptor …

WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1β induced inflammatory response by regulation of RUNX2/MMP13 …

X Liu, X Li, B Hua, X Yang, J Zheng, S Liu - Bone, 2021 - Elsevier
WNT16 has been shown to play important roles in joint formation, bone homeostasis and
knee joint osteoarthritis. However, whether WNT16 has any effect during …

Brief Report: Tumor Necrosis Factor and Interleukin‐6 Differentially Regulate Dkk‐1 in the Inflamed Arthritic Joint

N Yeremenko, K Zwerina, G Rigter, D Pots… - Arthritis & …, 2015 - Wiley Online Library
Objective Tumor necrosis factor (TNF) drives bone destruction, but it also inhibits new bone
formation by inducing Dkk‐1, an inhibitor of the Wnt pathway. Accordingly, blocking of Dkk‐1 …

Direct inhibition of NF-κB blocks bone erosion associated with inflammatory arthritis

JC Clohisy, BC Roy, C Biondo, E Frazier… - The Journal of …, 2003 - journals.aai.org
Inflammatory arthritis is associated with devastating joint tissue destruction and periarticular
bone erosion. Although secreted products of infiltrating immune cells perpetuate the …

Redox and NF-κB signaling in osteoarthritis

P Lepetsos, KA Papavassiliou… - Free Radical Biology and …, 2019 - Elsevier
Human cells have to deal with the constant production of reactive oxygen species (ROS).
Although ROS overproduction might be harmful to cell biology, there are plenty of data …