Brugada syndrome (BrS) is an inherited autosomal dominant cardiac channelopathy.
Pathogenic rare mutations in the SCN5A gene, encoding the alpha-subunit of the voltage …

Background Among rare channelopathies BrS patients are at high risk of sudden cardiac
death (SCD). SCN5A mutations are found in a quarter of patients. Other rare gene mutations …

SCN5A is abundant in heart and has a major role in I Na. Loss-of-function mutation in
SCN5A results in Brugada syndrome (BrS), which causes sudden death in adults. It remains …

Abstract Background Brugada syndrome (BrS) is an inherited cardiac arrhythmogenic
disease that predisposes patients to sudden cardiac death. It is associated with mutations in …

Brugada syndrome (BrS) is a cardiac arrhythmia disorder that causes sudden death in
young adults. Rare genetic variants in the SCN5A gene, encoding the Nav1. 5 sodium …

Abstract Aims Brugada syndrome (BrS) is associated with a pronounced risk to develop
sudden cardiac death (SCD). Up to 21% of patients are related to mutations in SCN5A …

Loss-of-function mutations of the SCN5A gene encoding for the sodium channel α-subunit
NaV1. 5 result in the autosomal dominant hereditary disease Brugada Syndrome (BrS) with …

The cardiac sodium channel (Nav1. 5) controls cardiac excitability by triggering the action
potential of cardiac myocytes and controlling electric impulse transmission. However, it has …

Variants in the sodium voltage-gated channel alpha subunit 5 gene (SCN5A) produce
variable cardiac phenotypes including Brugada syndrome, conduction disease and …

Brugada syndrome (BrS) is a complex genetic cardiac ion channel disease that causes a
high predisposition to sudden cardiac death. Considering that its heterogeneity in clinical …