Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.
CA DeMeester, X Bu, RJ Gray, AJ Lusis… - American journal of …, 1995 - ncbi.nlm.nih.gov
Abstract Lipoprotein (a)(Lp [a]) is a cholesterol-rich lipoprotein resembling LDL but also
containing a large polypeptide designated apolipoprotein (a)(apo [a]). Its levels are highly …
containing a large polypeptide designated apolipoprotein (a)(apo [a]). Its levels are highly …
The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration
HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …
Lp (a) concentration and apo (a) isoform size. Relation to the presence of coronary artery disease in familial hypercholesterolemia.
JF Bowden, PH Pritchard, JS Hill… - … and Thrombosis: A …, 1994 - Am Heart Assoc
We studied the relation between the concentration of lipoprotein (a)[Lp (a)] in plasma,
apolipoprotein (a)[apo (a)] phenotype, and the clinical expression of coronary artery disease …
apolipoprotein (a)[apo (a)] phenotype, and the clinical expression of coronary artery disease …
Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.
E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …
Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein (a) size and plasma lipoprotein (a) levels.
JC Cohen, G Chiesa, HH Hobbs - The Journal of clinical …, 1993 - Am Soc Clin Investig
Apolipoprotein (a)[apo (a)], an apolipoprotein unique to lipoprotein (a)[Lp (a)], is highly
polymorphic in size. Previous studies have indicated that the size of the apo (a) gene tends …
polymorphic in size. Previous studies have indicated that the size of the apo (a) gene tends …
Studies on apolipoprotein (a) phenotypes. Part 2. Phenotype frequencies and Lp (a) concentrations in different phenotypes in patients with angiographically defined …
A Abe, A Noma, YJ Lee, H Yamaguchi - Atherosclerosis, 1992 - Elsevier
In the present paper, we have evaluated serum Lp (a) concentrations, the frequencies of Lp
(a) phenotypes and alleles and the association between the Lp (a) phenotypes and serum …
(a) phenotypes and alleles and the association between the Lp (a) phenotypes and serum …
Apo (a) isoforms predict risk for coronary heart disease. A study in six populations.
C Sandholzer, N Saha, JD Kark, A Rees… - … and thrombosis: a …, 1992 - Am Heart Assoc
Elevated concentrations of lipoprotein (a)(Lp [a]) in plasma are associated with premature
coronary heart disease (CHD). Lp (a) levels are largely determined by alleles at the …
coronary heart disease (CHD). Lp (a) levels are largely determined by alleles at the …
Expressed hypervariable polymorphism of apolipoprotein (a).
MI Kamboh, RE Ferrell, BA Kottke - American journal of human …, 1991 - ncbi.nlm.nih.gov
Elevated plasma lipoprotein (a)(LP (a] levels are an independent predictor of the
development of premature atherosclerosis in humans. The LP (a) particle consists of two …
development of premature atherosclerosis in humans. The LP (a) particle consists of two …
[HTML][HTML] Relation of serum lipoprotein (a) concentration and apolipoprotein (a) phenotype to coronary heart disease in patients with familial hypercholesterolemia
M Seed, F Hoppichler, D Reaveley… - … England Journal of …, 1990 - Mass Medical Soc
Familial hypercholesterolemia carries a marked increase in the risk of coronary heart
disease (CHD), but there is considerable variation between individuals in susceptibility to …
disease (CHD), but there is considerable variation between individuals in susceptibility to …
A pentanucleotide repeat polymorphism in the 5'control region of the apolipoprotein (a) gene is associated with lipoprotein (a) plasma concentrations in Caucasians.
M Trommsdorff, S Köchl, A Lingenhel… - The Journal of …, 1995 - Am Soc Clin Investig
The enormous interindividual variation in the plasma concentrations of the atherogenic
lipoprotein (a)[Lp (a)] is almost entirely controlled by the apo (a) locus on chromosome 6q26 …
lipoprotein (a)[Lp (a)] is almost entirely controlled by the apo (a) locus on chromosome 6q26 …