[HTML][HTML] ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury

T Yamaguchi, M Hoshizaki, T Minato… - Nature …, 2021 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-
2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 …

[HTML][HTML] High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity

J Lu, PD Sun - Journal of Biological Chemistry, 2020 - ASBMB
The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a
pandemic and caused global public health crisis. Human angiotensin-converting enzyme 2 …

[HTML][HTML] Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19

K Kuba, T Yamaguchi, JM Penninger - Frontiers in immunology, 2021 - frontiersin.org
Seventeen years after the epidemic of SARS coronavirus, a novel coronavirus SARS-CoV-2-
emerged resulting in an unprecedented pandemic. Angiotensin-converting enzyme 2 …

SARS-CoV-2 spike protein destabilizes microvascular homeostasis

S Panigrahi, T Goswami, B Ferrari… - Microbiology …, 2021 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 infection can cause compromised respiratory function and
thrombotic events. SARS-CoV-2 binds to and mediates downregulation of angiotensin …

[HTML][HTML] Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection

AT Tang, DW Buchholz, KM Szigety, B Imbiakha… - Plos …, 2023 - journals.plos.org
Angiotensin-converting enzyme 2 (ACE2) is the cell-surface receptor for Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While its central role in Coronavirus …

[HTML][HTML] Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury

M Oz, DE Lorke - Biomedicine & Pharmacotherapy, 2021 - Elsevier
The recent emergence of coronavirus disease-2019 (COVID-19) as a pandemic affecting
millions of individuals has raised great concern throughout the world, and the severe acute …

SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2

AA Kiseleva, EM Troisi, SE Hensley… - The journal of …, 2021 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that
has given rise to the devastating global pandemic. In most cases, SARS-CoV-2 infection …

[HTML][HTML] A novel soluble ACE2 protein provides lung and kidney protection in mice susceptible to lethal SARS-CoV-2 infection

L Hassler, J Wysocki, I Gelarden, I Sharma… - Journal of the …, 2022 - journals.lww.com
Background Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-
length angiotensin converting enzyme 2 (ACE2) as a main receptor to enter target cells. The …

The discovery of angiotensin‐converting enzyme 2 and its role in acute lung injury in mice

Y Imai, K Kuba, JM Penninger - Experimental physiology, 2008 - Wiley Online Library
During several months of 2002, severe acute respiratory syndrome (SARS) caused by SARS‐
coronavirus (SARS‐CoV) spread rapidly from China throughout the world, causing more …

Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019

MY Liu, B Zheng, Y Zhang, JP Li - Chronic Diseases and …, 2020 - mednexus.org
Coronavirus disease 2019 is a major threat to public health globally. Though its
pathogenesis has not been fully elucidated, angiotensin-converting enzyme 2 (ACE2) has …