Lef1 regulates COX-2 transcription in chondrocytes

K Yun, SH Im - Biochemical and biophysical research communications, 2007 - Elsevier
Although the involvement of Wnt/β-catenin signaling pathway in the regulation of COX-2
expression has been suggested, the underlying molecular mechanisms are still unclear …

NF-κB regulates Lef1 gene expression in chondrocytes

K Yun, YD Choi, JH Nam, Z Park, SH Im - Biochemical and biophysical …, 2007 - Elsevier
The relation of Wnt/β-catenin signaling to osteoarthritis progression has been revealed with
little information on the underlying molecular mechanism. In this study we found …

[HTML][HTML] Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathway

SG Hwang, SS Yu, SW Lee, JS Chun - FEBS letters, 2005 - Elsevier
Our previous study indicated that interleukin (IL)-1β induces expression of several Wnt
proteins in chondrocytes and causes chondrocyte dedifferentiation via the c-Jun/activator …

Lymphoid enhancer binding factor 1 regulates transcription through gene looping

K Yun, JS So, A Jash, SH Im - The Journal of Immunology, 2009 - journals.aai.org
Efficient transcription depends upon efficient physical and functional interactions between
transcriptosome complexes and DNA. We have previously shown that IL-1β-induced …

Transcriptional regulation of MMP13 by Lef1 in chondrocytes

K Yun, SH Im - Biochemical and biophysical research communications, 2007 - Elsevier
An association between Wnt/β-catenin signaling and MMP13 expression has been reported
but there has been little information about the underlying mechanism. Here, we investigated …

β-Catenin regulates expression of cyclooxygenase-2 in articular chondrocytes

SJ Kim, DS Im, SH Kim, JH Ryu, SG Hwang… - Biochemical and …, 2002 - Elsevier
Pro-inflammatory cytokine such as interleukin (IL)-1β causes inflammation of articular
cartilage via induction of cyclooxygenase (COX)-2 expression. We investigated in this study …

The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner

F Yano, F Kugimiya, S Ohba, T Ikeda, H Chikuda… - Biochemical and …, 2005 - Elsevier
To better understand the role of the canonical Wnt signaling pathway in cartilage
development, we adenovirally expressed a constitutively active (ca) or a dominant negative …

[HTML][HTML] T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor κB signaling

B Ma, L Zhong, CA van Blitterswijk, JN Post… - Journal of Biological …, 2013 - ASBMB
T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are downstream
effectors of Wnt/β-catenin signaling, which has been implicated in the development and …

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor

YF Dong, DY Soung, EM Schwarz… - Journal of cellular …, 2006 - Wiley Online Library
We investigated the molecular mechanisms underlying canonical Wnt‐mediated regulation
of chondrocyte hypertrophy using chick upper sternal chondrocytes. Replication competent …

ESE‐1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes

H Peng, L Tan, M Osaki, Y Zhan, K Ijiri… - Journal of cellular …, 2008 - Wiley Online Library
The epithelium‐specific ETS (ESE)‐1 transcription factor is induced in chondrocytes by
interleukin‐1β (IL‐1β). We reported previously that early activation of EGR‐1 by IL‐1β …