Insulin secretion from pancreatic β-cells is the only efficient means to decrease blood
glucose concentrations. Glucose is the principal stimulator of insulin secretion with the ATP …

In the normal human body pancreatic β-cells spend most of the time in a READY mode
rather than in an OFF mode. When in the READY mode, normal β-cells can be easily …

There are eight thermosensitive TRP (transient receptor potential) channels in mammals,
and there might be other TRP channels sensitive to temperature stimuli. Here, we …

To date, 11 thermosensitive transient receptor potential (thermo-TRP) channels have been
identified. Recent studies have characterized the mechanism of thermosensing by thermo …

Transient receptor potential channels have been put forward as regulators of insulin
secretion. A role for the TRPV1 ion channel in insulin secretion has been suggested in …

Insulin secretion from pancreatic β-cells is the primary mechanism by which the body lowers
blood glucose concentrations. Glucose is the principal stimulator of insulin secretion, and …

Objective Members of the transient receptor potential (TRP) channels are involved in
mediating the electrical excitability and stimulus-secretion coupling in the pancreatic β-cells …

OBJECTIVE—Calcium-permeable cation channel TRPV2 is expressed in pancreatic β-cells.
We investigated regulation and function of TRPV2 in β-cells. RESEARCH DESIGN AND …

Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients
such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1). The …

During the last three to four decades the prevalence of obesity and diabetes mellitus has
greatly increased worldwide, including in the United States. Both the short-and long-term …