Amiodarone, an antiarrhythmic drug toxic toward the lung, is metabolized through sequential
modifications of the diethylaminoethoxy group to mono-N-desethylamiodarone (MDEA), di-N …

Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …

Amiodarone is a clinically effective antiarrhythmic drug shown to cause lung damage in
humans and animals. While the mechanism of this pulmonary toxicity is unknown, it may be …

Administration of the antiarrhythmic drug amiodarone to humans or animals may result in
lung damage. Amiodarone is metabolized to desethylamiodarone and other minor …

Toinvestigate the relationship between the amount of amiodarone and the major metabolite
N-desethylamiodarone found in the lung with the development of toxicity, Fischer 344 and …

The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …

Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-
threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may …

Amiodarone (AD) has been shown to produce a transient pulmonary fibrosis in hamsters
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …

Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …

Amiodarone (AMI) is a potent antiarrhythmic agent; however, its clinical use is limited due to
numerous side effects. In order to investigate the structure–cytotoxicity relationship, AMI …