Mitochondria, as the powerhouse organelle of cells, are greatly involved in regulating cell
signaling pathways, including those related to the innate and acquired immune systems …

Asthma is a complex, inflammatory disorder characterized by airflow obstruction of variable
degrees, bronchial hyper-responsiveness, and airway inflammation. Asthma is caused by …

Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

Though severe or refractory asthma merely affects less than 10% of asthma population, it
consumes significant health resources and contributes significant morbidity and mortality …

There is increasing appreciation that mitochondria serve cellular functions beyond oxygen
sensing and energy production. Accordingly, it has become important to explore …

Abstract Purpose of the Review The connections between allergy, asthma and metabolic
syndrome are becoming increasingly clear. Recent research suggests a unifying …

Mitochondria are indispensable for energy metabolism and cell signaling. Mitochondrial
homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of …

Mitochondria are biosynthetic, bioenergetic, and signaling organelles which are critical for
physiological adaptations and cellular stress responses to the environment. Various …

Obesity not only increases the risk of asthma, but also, contributes significantly to its clinical
heterogeneity. Obese asthmatics exhibit a distinct clinical phenotype characterized by …

An imbalance between Th1 and Th2 immune response is crucial for the development of
pathophysiological features of asthma. A Th2-dominant response produces oxidative stress …