Progressive weakness remains the clinical hallmark of amyotrophic lateral sclerosis (ALS).
Accordingly, a variety of tools has been developed to capture this disease feature, including …

Background: Pathologic changes in the motor cortex and corticospinal tracts in ALS may be
reflected by abnormal signal intensities on conventional MRI. The sensitivity of these …

OBJECTIVE: Preferential wasting of the thenar group of muscles, the split hand sign,
appears to be a specific feature of ALS. The present study developed a novel split-hand …

Up to half of patients with ALS develop cognitive impairment during the course of the illness.
Despite this, there is no simple tool for screening patients in the clinical setting. This study …

Objective: Patients with amyotrophic lateral sclerosis (ALS) not only show motor deficits, but
may also have cognitive and/or behavioral impairments. Recognizing these impairments is …

Objective: Examine sequence of weakness in arm muscles from longitudinal hand-held
dynamometry (HHD) data in ALS for congruence with contiguous spread of …

Objective To determine the relative contribution of inhibitory and facilitatory circuits in the
development of cortical hyperexcitability in amyotrophic lateral sclerosis (ALS). Methods In …

The progressive course of amyotrophic lateral sclerosis (ALS) results in an ever-changing
spectrum of the care needs of patients with ALS. Knowledge of prognostic factors for the …

Abstract Background The ALS Functional Rating Scale in its revised version (ALSFRS-R) is
a disease-specific severity score that reflects motor impairment and functional deterioration …

Objective Cortical hyperexcitability has been established as an early feature of amyotrophic
lateral sclerosis (ALS). The evolution of cortical hyperexcitability with ALS progression …