INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …

Mammalian skin research represents the convergence of three complementary disciplines:
cell biology, mouse genetics, and dermatology. The skin provides a paradigm for current …

Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to
local signals. ILCs are traditionally classified as ILC1, ILC2 or ILC3 on the basis of their …

Perturbations in the transcriptional programs specifying epidermal differentiation cause
diverse skin pathologies ranging from impaired barrier function to inflammatory skin disease …

The blood and immune systems develop in parallel during early prenatal life. Waves of
hematopoiesis separated in anatomical space and time give rise to circulating and tissue …

Many adult regenerative cells divide infrequently but have high proliferative capacity. We
developed a strategy to fluorescently label slow-cycling cells in a cell type–specific fashion …

Inflammatory response heterogeneity has impeded high-resolution dissection of diverse
immune cell populations during activation. We characterize mouse cutaneous immune cells …

Background The heterogeneous functions of dermal myeloid cells in antigen presentation,
and scavenging pathogens and cell debris places them centrally in cutaneous inflammation …

The skin comprises tissue macrophages as the most abundant resident immune cell type.
Their diverse tasks including resistance against invading pathogens, attraction of bypassing …

The skin provides the first line defense of the human body against injury and infection. By
integrating recent findings in cutaneous immunology with fundamental concepts of skin …