Deciphering the mechanism for induction of senescence-associated secretory phenotype (SASP) and its role in ageing and cancer development
N Ohtani - The journal of biochemistry, 2019 - academic.oup.com
Cellular senescence is an irreversible form of cell cycle arrest that can be induced by
persistent DNA damage, and is well known to function as an important tumour suppression …
persistent DNA damage, and is well known to function as an important tumour suppression …
[HTML][HTML] The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?
N Ohtani - Inflammation and regeneration, 2022 - Springer
Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli, including DNA damage. Hence, senescence has …
variety of potentially oncogenic stimuli, including DNA damage. Hence, senescence has …
Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases
S Watanabe, S Kawamoto, N Ohtani, E Hara - Cancer science, 2017 - Wiley Online Library
“Cellular senescence” is a state in which cells undergo irreversible cell cycle arrest in
response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to …
response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to …
Assessing functional roles of the senescence-associated secretory phenotype (SASP)
N Malaquin, V Tu, F Rodier - Cellular Senescence: Methods and Protocols, 2019 - Springer
Cellular senescence is linked to many normal biological processes, including tumor
suppression, development, and wound healing, but it is also associated with age-related …
suppression, development, and wound healing, but it is also associated with age-related …
Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
N Ohtani, E Hara - Cancer science, 2013 - Wiley Online Library
Cellular senescence is the state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …
Pro-and anti-tumorigenic functions of the senescence-associated secretory phenotype
L Lau, G David - Expert opinion on therapeutic targets, 2019 - Taylor & Francis
Introduction: Cellular senescence is a stable form of cell cycle exit. Though they no longer
divide, senescent cells remain metabolically active and secrete a plethora of proteins …
divide, senescent cells remain metabolically active and secrete a plethora of proteins …
The senescence-associated secretory phenotype and its regulation
S Lopes-Paciencia, E Saint-Germain, MC Rowell… - Cytokine, 2019 - Elsevier
The senescence-associated secretory phenotype (SASP) defines the ability of senescent
cells to express and secrete a variety of extracellular modulators that includes cytokines …
cells to express and secrete a variety of extracellular modulators that includes cytokines …
Cellular senescence: a link between cancer and age-related degenerative disease?
Cellular senescence is an established cellular stress response that acts primarily to prevent
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …
Potential regulators of the senescence-associated secretory phenotype during senescence and aging
X Han, Q Lei, J Xie, H Liu, J Li, X Zhang… - The Journals of …, 2022 - academic.oup.com
Senescent cells express and secrete a variety of extracellular modulators that include
cytokines, chemokines, proteases, growth factors, and some enzymes associated with …
cytokines, chemokines, proteases, growth factors, and some enzymes associated with …