Conspectus Incorporation of chemically modified nucleotide scaffolds into nucleic acids to
form assemblies rich in function is an innovative area with great promise for nanotechnology …

Oligonucleotides (ONs) modified with a 2′-N-(pyren-1-yl) acetyl-2′-amino-α-L-LNA
thymine monomer Y flanked on the 3′-side by an abasic site Φ (ie, YΦ-unit) exhibit …

N2′-Pyrene-functionalized 2′-amino-α-L-LNAs (locked nucleic acids) display
extraordinary affinity toward complementary DNA targets due to favorable preorganization of …

Mono-and diaminated 2′-amino-LNA monomers were synthesized and introduced into
oligonucleotides. Each modification imparts significant stabilization of nucleic acid duplexes …

The synthesis of 2′-amino-LNA (the 2′-amino derivative of locked nucleic acid) has
opened up a number of exciting possibilities with respect to modified nucleic acids. While …

Fluorophore-modified oligonucleotides have found widespread use in genomics and enable
detection of single-nucleotide polymorphisms, real-time monitoring of PCR, and imaging of …

Oligonucleotides composed of naturally occurring nucleic acids are unsuitable for many
therapeutic and biotechnological applications because of their poor biostability. Numerous …

Complementary locked nucleic acid (LNA) and peptide nucleic acid (PNA) hexamers bind to
each other with significantly higher affinity than each binds to DNA, and with far greater …

Oligonucleotides are key compounds widely used for research, diagnostics, and
therapeutics. The rapid increase in oligonucleotide-based applications, together with the …

Abstract Locked Nucleic Acid (LNA) is a unique nucleic‐acid modification possessing very
high binding affinity and excellent specificity toward complementary RNA or DNA …